Planting Seeds for the Future

Planting Seeds for the Future

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  • Excellence in Scholarship: Vet Med Faculty Publications

    Endometrial decidualization: Of mice and men

    Seminars in Reproductive Medicine
    Volume 28, Issue 1, 2010, Pages 17-26

    Ramathal, C.Y(a)., Bagchi, I.C.(b), Taylor, R.N.(d), Bagchi, M.K.(c)

    a  Department of Cell and Developmental Biology, University of Illinois-Urbana-Champaign, Urbana, IL, United States
    b  Department of Veterinary Biosciences, University of Illinois-Urbana-Champaign, Urbana, IL, United States
    c  Molecular and Integrative Physiology, University of Illinois-Urbana-Champaign, 407 S. Goodwin Ave., Urbana, IL 61801, United States
    d  Department of Gyn/Ob, Emory University School of Medicine, Atlanta, Georgia


    In murine and human pregnancies, embryos implant by attaching to the luminal epithelium and invading into the stroma of the endometrium. Under the influence of the steroid hormones estrogen and progesterone, the stromal cells surrounding the implanting embryo undergo a remarkable transformation event. This process, known as decidualization, is an essential prerequisite for implantation. It comprises morphogenetic, biochemical, and vascular changes driven by the estrogen and progesterone receptors. The development of mutant mouse models lacking these receptors has firmly established the necessity of steroid signaling for decidualization. Genomic profiling of mouse and human endometrium has uncovered a complex yet highly conserved network of steroid-regulated genes that supports decidualization. To advance our understanding of the mechanisms regulating implantation and better address the clinical challenges of infertility and endometrial diseases such as endometriosis, it is important to integrate the information gained from the mouse and human models. Copyright © 2010 by Thieme Medical Publishers, Inc.

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