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Speaker
| | William B. Helferich, Professor Food Science and Human Nutrition, Nutritional Sciences, University of Illinois |
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| | Date | | Oct 12, 2009 |
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| | Time | | 12:00 pm
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| | Location | | Room 1000 Micro and Nano Laboratory, 208 N. Wright St., Urbana, IL |
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| | Sponsor | | College of Veterinary Medicine and Division of Biomedical Sciences |
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| | Contact | | Nikki Hausmann |
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| | E-Mail | | nhausman@illinois.edu |
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| | Phone | | (217) 333-4291 |
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| | Event type | | Seminar |
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| | Views | | 879 |
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| Genistein, found in soy products, is a phytochemical with estrogenic activity. Our research has focused on the effects dietary genistein on growth of estrogen (E)-dependent mammary tumors both in vitro and in vivo. Genistein enhances the proliferation of E-dependent human breast cancer tumor growth. Genistin, the glycoside form of genistein simulates growth similar to that of genistein and withdrawal of either genistin results in tumor regression. We have also demonstrated that soy protein isolates processed to contain low, medium and high amounts of isoflavones simulate tumor growth in a dose dependent manner. Expression of the estrogen-responsive gene, pS2 was also induced in response to treatment with dietary genistein.
Genistein can act as an estrogen agonist resulting in proliferation of E-dependent human breast cancer cells in vivo and can negate the inhibitory effects of TAM and AIs on E-stimulated growth of MCF-7 cell tumors (in vivo) implanted into ovariectomized athymic mice. These results warrant caution for women with estrogen-dependent BC regarding consumption of isoflavone-containing dietary supplements and soy ingredients high in isoflavones. |
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