MCB Seminars-School of Molecular and Cellular Biology Seminars

MCB Seminars-School of Molecular and Cellular Biology Seminars

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Event Detail Information

Event Detail Information

Speaker Dr. Brian Kuhlman
Date Oct 4, 2013
Time 12:00 pm - 1:00 pm  
Location Charles G. Miller Auditorium (B102 CLSL)
Cost Free
Contact Cara L. Day
Phone 217.333.2013
Event type Seminar
Views 3539
The molecular modeling program Rosetta has been used to design novel protein-protein interactions and protein switches that respond to light. The designed interactions make use of stabilizing anchor points such as metal binding and Beta-strand interactions. The designed photoactivable proteins incorporate the naturally occurring LOV domain from plants, and show increased binding affinity for specified binding partners in the light. These binding events have been used to control gene transcription and protein localization with blue light.
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