MCB Seminars-School of Molecular and Cellular Biology Seminars

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Biochemistry Seminar: Dr. Brian Kuhlman, University of North Carolina at Chapel Hill "Computational Design of Protein Interactions and Switches"

Event Type
Dr. Yi Lu and Emad Tajkhorshid
Charles G. Miller Auditorium (B102 CLSL)
Oct 4, 2013   12:00 - 1:00 pm  
Dr. Brian Kuhlman
Originating Calendar
Biochemistry Department Seminars

The molecular modeling program Rosetta has been used to design novel protein-protein interactions and protein switches that respond to light.  The designed interactions make use of stabilizing anchor points such as metal binding and Beta-strand interactions.  The designed photoactivable proteins incorporate the naturally occurring LOV domain from plants, and show increased binding affinity for specified binding partners in the light.  These binding events have been used to control gene transcription and protein localization with blue light.

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