MCB Seminars-School of Molecular and Cellular Biology Seminars

MCB Seminars-School of Molecular and Cellular Biology Seminars

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Event Detail Information

Event Detail Information

Speaker Dr. Eric Schmidt
Date Mar 8, 2013
Time 12:00 pm - 1:00 pm  
Location B102 CLSL
Cost Free
Sponsor

Dr. Satish Nair

Contact Cara L. Day
Phone 217.333.2013
Event type Seminar
Views 2152
Originating Calendar Biochemistry Department Seminars
ABSTRACT: Cyanobactins are ribosomally derived peptide natural products that are extensively posttranslationally modified. In exploring the biosynthesis of diverse cyanobactins in nature, we found that the enzyme sequences are highly similar (often, identical) despite producing diverse substrates. We have been working to understand these multistep pathways, where the enzymes are relatively fixed while the substrates undergo substantial modification. In so doing, we have also examined the chemical mechanisms underlying some of the posttranslational tailoring steps and synthesized diverse derivatives in vivo and in vitro for drug discovery.