Fluid physics at nanometer scale can be quite different from its macroscopic counterpart. Advances in elucidating fluid phenomena at nanoscale can enable revolutionary advances in numerous applications in engineering and science. Several experimental approaches have been used with increasing success in recent years to characterize fluid transport through nanopores of varying diameters. However, many fundamental questions concerning fluid physics still remain. For example, how does confinement affect fluid phenomena? In this talk, we will discuss how computational approaches can provide fundamental and unique insights into fluid physics at nanoscale. The traditional continuum theory fails to take into account the effects caused by the finite size of the fluid molecules and the fluid accessible volume of the nanopore. This requires atomic scale simulations (e.g. molecular dynamics simulations) where finite size of the fluid molecules is explicitly treated. However, order of the time scales and the length scales possible in atomistic molecular dynamics (MD) simulations is far less than realistic design calculations. In this talk, we will discuss structure and dynamics of fluids in confined environments, e.g. nanopores. The interfacial structure of fluids is computed by a multiscale quasi-continuum theory. The results from quasi-continuum theory compare well with molecular dynamics (MD) and the quasi-continuum theory is several orders of magnitude faster compared to MD. The structure obtained from the multiscale theory is coupled with the particle transport equation to compute dynamics in nanopores. We will discuss several applications of fluid transport through nanopores.