The School of Molecular and Cellular Biology at the University of Illinois at Urbana-Champaign

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Event Detail Information

Event Detail Information

Speaker

Dr. Eric Schmidt

Date Mar 8, 2013
Time 12:00 pm - 1:00 pm  
Location

B102 CLSL

Cost

Free

Contact

Cara L. Day

Phone 217.333.2013
Event type Seminar
Views 2152

ABSTRACT:  Cyanobactins are ribosomally derived peptide natural products that are extensively posttranslationally modified. In exploring the biosynthesis of diverse cyanobactins in nature, we found that the enzyme sequences are highly similar (often, identical) despite producing diverse substrates. We have been working to understand these multistep pathways, where the enzymes are relatively fixed while the substrates undergo substantial modification. In so doing, we have also examined the chemical mechanisms underlying some of the posttranslational tailoring steps and synthesized diverse derivatives in vivo and in vitro for drug discovery.

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