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Biochemistry Seminar: Dr. Marina Ramirez-Alvarado, Mayo Clinic "When antibodies misbehave: Mechanisms of amyloid formation in Light Chain Amyloidosis"

Event Type
Seminar/Symposium
Sponsor
SACNAS - Manuel A. Ortega and partially funded by SORF
Location
B102 CLSL
Date
Mar 29, 2013   12:00 - 1:00 pm  
Speaker
Dr. Marina Ramirez-Alvarado
Cost
Free
Originating Calendar
Biochemistry Department Seminars

ABSTRACT:  The Ramirez-Alvarado team is interested in understanding the molecular mechanisms that promote protein misfolding in the context of human disease. Our team has focused its studies on Light Chain Amyloidosis, a fatal protein misfolding disease associated with a malignancy.  The disease is characterized by abnormal proliferation of plasma cells that secret large amounts of free immunoglobulin light chains.  These light chains then misfold and aggregate as amyloid fibrils in vital organs, causing organ failure and death.  Our research program is interested in determining the mutations responsible for amyloid formation and the structural basis of light chain derived toxicity.

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