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Herbert E. Carter Lecture in Nutritional Biochemistry and Preventive Medicine: Dr. Paul Schimmel (The Scripps Institute), "Nature’s Repurposing of Human tRNA Synthetases for Cell Signaling"

Event Type
Seminar/Symposium
Topic
academic
Sponsor
Dr. Susan Martinis
Location
Charles G. Miller Auditorium (B102 CLSL), 601 S. Goodwin Avenue, Urbana
Date
Sep 15, 2017   4:00 pm  
Speaker
Dr. Paul Schimmel
Cost
Free
Registration
Registration
Contact
Cara Day
E-Mail
caraday@illinois.edu
Phone
217-333-2013
Views
60
Originating Calendar
Biochemistry Department Seminars

ABTRACT: 

The 20 aminoacyl tRNA synthetases arose early in evolution as agents of decoding genetic information for protein synthesis in the cytoplasm.  And yet, in humans they are associated with many human diseases where no defect in protein synthesis is found. These diseases and other physiological connections are associated with their re-purposing, through secreted and nuclear forms. These associations are correlated with their long evolutionary history, during which the synthetases progressively added new domains in an accretive way. These domains are dispensable for the function in protein synthesis. Unexpectedly, the fecundity of these architectural decorations appears to be unmatched by any other protein family. New functions emanate from these decorations, and are captured by the more than 200 natural splice variants, many of which are repurposed by ablating the catalytic domain while retaining the novel ones. These finding have led to the implementation of many applications for disease intervention.

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