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Event Detail Information

SpeakerDr. Josh Wand
Date Nov 1, 2013
Time 12:00 pm - 1:00 pm  
Location Charles G. Miller Auditorium, Room B102 Chemical & Life Sciences Laboratory
Cost Free
Sponsor Dr. Stephen G. Sligar
Contact Cara L. Day
Phone 217.333.2013
Event type Seminar
Views 2413

ABSTRACT:  The role of conformational entropy in molecular recognition by proteins has been elusive, mostly because it has been difficult to measure. We have recently developed an empirical "entropy meter" based on a dynamical proxy that is accessed by NMR relaxation methods. Kasinath, V., Sharp, K. A. and Wand, A. J. (2013) Microscopic insights into the NMR relaxation based protein conformational entropy meter. J. Am. Chem. Soc. 135, 15092-15100. Wand, A. J. (2013) The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation. Cur. Opinion Struct. Biol. 23, 75 – 81. Marlow, M. S., Dogan, J., Frederick, K. K., Valentine, K. G., and Wand, A. J. (2010) The role of conformational entropy in molecular recognition by calmodulin.  Nature Chem. Biol. 6, 353 – 358. Frederick, K. K., Marlow, M. S., Valentine, K. G. and Wand, A. J. (2007) Conformational entropy in molecular recognition by proteins. Nature 448, 325 – 329

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