College of LAS Events

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Event Detail Information

SpeakerDr. Hau Lou
Date Feb 28, 2014
Time 12:00 pm  
Location Charles G. Miller Auditorium (B102 CLSL)
Cost Free
Sponsor Dr. Auinash Kalsotra
Contact Cara Day
Phone 217-333-2013
Event type Seminar/Symposium
Views 2968

ABSTRACT: In contrast to the well-studied regulation of tissue- and developmental stage-specific alternative splicing. The regulated alternative splicing changes in cells responding to environmental cues is poorly understood. Using neonatal mouse cardiomyocytes, we found that elevated intracellular calcium levels lead to significantly increased skipping of exons for several genes. Our further investigations have uncovered a novel epigenetic regulatory network that integrates histone modification, chromatin structure, transcriptional elongation and alternative splicing. Reference: Zhou et al 2011 Proc Natl Acad Sci

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