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Statistics Seminar: Quantile secondary analysis for case-control studies with applications to GWAS data, Dr. Ying Wei, Columbia University

Speaker Dr. Ying Wei
Date Feb 27, 2014
Time 4:00 pm  
Location 165 Everitt Lab
Sponsor Department of Statistics
Event type Seminar
Views 1724
Originating Calendar Department of Statistics
Case-control designs are used widely in epidemiology and other fields to identify the factors that may contribute to a disease of interest. In these studies, analyzing associations with secondary outcomes, which are biomarkers of the underlying disease, is another important way to understand the disease progress and mechanism. Most of the existing methods have been developed for inference on the mean of the secondary outcomes. In this paper, we propose a quantile-based approach. We construct a new family of estimating equations to make consistent and efficient estimation of conditional quantiles using the entire case-control sample, and also develop related statistical tools for inference. Simulations are conducted to evaluate the practical performance of the proposed approach, and a case-control study on genetic association with asthma is used to demonstrate the method.
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