Center for Clinical and Translational Sciences Events
Center for Clinical and Translational Sciences Events
import, export, and share options
advanced search
view calendar
| week selector | S | M | T | W | T | F | S |
|---|---|---|---|---|---|---|---|
go to week of Nov 25, 2012 | 25 | 26 | 27 | 28 | 29 | 30 | 1 |
| go to week of Dec 2, 2012 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| go to week of Dec 9, 2012 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| go to week of Dec 16, 2012 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
 | 23 | 24 | 25 | 26 | 27 | 28 | 29 |
| go to week of Dec 30, 2012 | 30 | 31 | 1 | 2 | 3 | 4 | 5 |
Event Detail Information
Event Detail Information
The Department of Biochemistry and Molecular Genetics: "The balance between Tcf-1 and beta-catenin is critical to secure genome stability in thymocytes"
Title: "The balance between Tcf-1 and beta catenin is critical to secure genome stability in thymocytes"
Speaker: Dr. Fotini Gounari, Knapp Center for Lupus and Immunology Research, University of Chicago
The T-cell specific HMG domain factor Tcf-1 depends on its interaction with β-catenin to promote gene transcription. We show here that Tcf-1, one of the most abundantly expressed genes in double positive (DP) thymocytes, binds actively transcribing loci despite limiting amounts of β-catenin. Tcf-1, and RAG2 overlap at common histone-3-tri-methylated at lysine-4 chromatin sites genome-wide. In addition, Tcf-1 binds the DNA-repair protein Ku70 and elevated b-catenin levels outcompete this interaction resulting in altered resolution of RAG induced DNA-double-strand-breaks and increased DNA-damage. At the same time, elevated b-catenin levels enable survival of cells with damaged DNA. This combination culminates in RAG-dependent lymphomas with recurring Tcra/Myc oncogenic translocations. Our findings reveal a novel Tcf-1 function in DNA-repair that is controlled by b-catenin and
suggest how it can be compromised in carcinogenesis.
© Copyright 2010 The Board of Trustees of the University of Illinois
