University of Illinois, Department of Bioengineering, College of Engineering; Engineering For Life.
  Seminars and Lectures calendar.

The Department of Bioengineering maintains this calendar of seminars, which includes seminars sponsored by the department and those that may be of interest to Bioengineering students, faculty or alumni. All seminar titles are preceded by the sponsoring unit's name or acronym for quick identification.

If you have a seminar you wish to include here, please send complete information for consideration to: Susan McKenna, Assistant Director of Communications, Department of Bioengineering, mckenna1 at illinois dot edu.

Bioengineering Seminars

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Event Detail Information

BIOENGINEERING: The Cell by Cell Chemical Characterization of the Brain: from New Tools to New Insights

Speaker Dr. Jonathan Sweedler, Professor of Chemistry, Illinois
Date Nov 7, 2013
Time 12:00 pm  
Location 2240 DCL
Sponsor Department of Bioengineering
Event type Graduate
Views 1590
In the postgenomic era, one expects the suite of chemical players in a brain region to be known and their functions uncovered. However, many cell-to-cell signaling molecules remain poorly characterized and for those that are known, their localization and dynamics are oftentimes unknown. A suite of bioanalytical / bioengineering approaches are described that allow the investigation of individual neurons and small brain regions; these approaches include capillary scale separations coupled to mass spectrometry and direct mass spectrometric-based profiling and imaging. Several applications of single cell microanalysis are highlighted: investigating novel indolamine neurochemistry, determining the role of d-aspartate in the brain, and characterizing the peptides in single cells. Specifically, new serotonin-related compounds and literally hundreds of new neuropeptides have been characterized in well-defined neuronal networks, and in several cases, the functional roles of these molecules described. Imaging mass spectrometry and dynamic sampling of the extracellular environment are used for elucidating novel cell to cell signaling molecules in a range of neuronal model systems. Current technology efforts involve extending the depth of metabolome coverage and adapting these analytical approaches to higher throughput single cell assays. Our overarching goal is to uncover the complex chemical mosaic of the brain and pinpoint key cellular players in physiological and pathological processes. Several additional examples of neuropeptide and neuromodulator discovery are described across a range of metazoan life.
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