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"Next-Generation Quantum Dot Probes for Bioimaging"
Quantum dots (QDs) are fluorescent nanocrystals that have recently emerged as a new class of biological label with outstanding photostability and emission intensity. This seminar will discuss new mechanisms for engineering the size, optical properties, and surface chemistry of these probes for use in single molecule imaging in living cells and for imaging in noisy tissue in vivo. We have recently developed a new optical characterization methodology for these nanocrystals that allows high-resolution determination of nanomaterial structure that we are using to synthesize a new generation of quantum dots with minimized size, broadened spectral tunability, and equal brightness across multiple colors. We are using these new probes to image the microscopic processes of vascular delivery of multiple nanoparticle formulations, which can be systematically and quantitatively compared in mammary tumors using multicolor intravital microscopy, and to understand molecular mechanisms underlying carcinogenesis.
Andrew M. Smith, PhD, is an assistant professor of Bioengineering at Illinois. Dr. Smith received a BS in chemistry in 2002 and a PhD in bioengineering in 2008, both from the Georgia Institute of Technology. He trained with Professor Shuming Nie as a graduate student and Whitaker Foundation Fellow and continued his postdoctoral studies at Emory University as a Distinguished CCNE Fellow and NIH K99 Postdoctoral Fellow. Dr. Smith's research interests include nanomaterial engineering, single-molecule imaging, and cancer biology.