Center for Biophysics and Quantitative Biology Master Calendar

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The complexities of targeting nanoparticles into solid tumors

Event Type
Center for Cellular Mechanics
1000 MNTL
Nov 5, 2013   12:00 pm  
Dr. Warren Chan, Professor, University of Toronto
Originating Calendar
Bioengineering calendar

Nanoparticles of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics. Strategies that can reproducibly prepare colloidal nano-particles of a wide range of geometries with a tight size distribution have been achieved and unique size and shape dependent optical, magnetic, electrical, and biological properties have been discovered. A broad of range of applications of nanoparticles have been demonstrated. In spite of what has been achieved so far, a complete understanding of how cells and animals interact with nanoparticles of well-defined sizes remains poorly understood.

This has led to the inability to rationally design nano-particles for cancer applications or has led to the inability to establish a definitive conclusion on the toxicity of nanomaterials. In this presentation, the properties of nanomaterials and challenges associated with using them for cancer targeting will be discussed, and finally, there will be a discussion on how microfluidics and DNA assembly techniques can be exploited to address the current limitations of nanomedicine.

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