Is nuclear disarmament technically feasible? What are the technical challenges to verifying that a formerly nuclear-armed nation has completely dismantled its nuclear arsenal? What is the feasibility of achieving and verifying that fissile material is no longer produced for weapons purposes? Will keeping stockpiles of weapons-usable material pose a show-stopper for disarmament? What is the role of missile defense in a nuclear-weapon-free world? The presenter will discuss these and other challenges and physicists' role in meeting them.