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Event Detail Information

PATH Seminar-Eric M. Poeschla, M.D.

Speaker Eric M. Poeschla, M.D., Mayo Clinic, Dept. of Infectious Diseases
Date Apr 24, 2013
Time 12:00 pm  
Location 2271-C Veterinary Medicine Basic Sciences Building
Sponsor Pathobiology Seminar Series
Phone 217-244-8924
Event type Seminar
Views 738
Originating Calendar Pathobiology Calendar
Title: Developing Novel Models of AIDS Virus Resistance and Disease. The feline AIDS virus, FIV, is very similar to HIV-1 in genetic structure and immune pathophysiology. In addition, species-specific innate immune defenses (restrictions) in the cat parallel primate systems. We have enabled feline transgenesis in order to acquire the unprecedented capability to experimentally manipulate the genome of an AIDS lentivirus-susceptible animal. The goals are to better understand AIDS virus pathogenesis and to model adaptation of host dependency and restriction factor biology to gene therapy for HIV-1 disease.