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Special Seminar: "The impact of network structure on criticality in cortical circuits"

SpeakerJohn Beggs, Associate Professor of Biophysics, Indiana University at Bloomington
Date May 13, 2013
Time 12:00 pm  
Location 144 Loomis
Sponsor Center for the Physics of Living Cells
Contact Stephanie Johansson
Phone 217-300-4241
Event type Seminar/Symposium
Views 1845

Cortical circuits have been hypothesized to operate near a critical point for optimality. Previous evidence supporting this came from bulk signals that did not show individual neuron activity. Using a 512 electrode array, we recorded up to seven hundred spiking neurons simultaneously and found two main things: (1) Avalanche shapes can be collapsed onto a universal scaling function, a key indicator of criticality; (2) The network structure of effective connections strongly influences dynamics. Cortical circuits not operating at the critical point may be associated with neuropathologies, so mechanisms maintaining critical network structure may be essential for neurological health.

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