Title: "A Tooth Problem: Biomodification of Dentin Matrices as Novel Strategy for Dental Therapies"
Speaker: Prof. Ana Bedran-Russo, Associate Professor and Director of Applied Dental Materials and Interfaces at UIC College of Dentistry
It is estimated that in the United States, 350 million dental restorations (fillings) are placed every year in dental offices. Sixty percent of those restorations replace existing failed restorative treatments. The primary reason for failure of dental restorations is secondary caries (decay), indicative of increased permeability and debonding between tooth and restorative biomaterial. Current dental adhesive restorative systems rely on the micromechanical retentions of restorations by infiltrations of hydrophilic and hydrophobic resins into a collagen-rich surface on dentin. Our laboratory at UIC has focused on understanding the tooth biochemistry/biomechanics and explored biomimetic approaches for innovative restorative/regenerative therapies. Specifically, the interactions of olygomeric proanthocyanidins agents (OPC) with dentin matrices to improve mechanical properties and reduced biodegradation rates. This presentation will provide (1) overview of challenges in the harsh oral environment, (2) limitations of current dental therapies, and (3) mechanisms of interactions of OPC with type I collagen, proteoglycans, and matrix metalloproteinases (MMPs).
Coffee and cookies will be served.