Seminars of Interest

Seminars of Interest

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Event Detail Information

Event Detail Information

Date Apr 5, 2013
Time 12:00 pm - 1:00 pm  
Location B102 CLSL
Cost Free
Sponsor

Dr. Susan Martinis

 

Contact Cara L. Day
Phone 217.333.2013
Event type Seminar
Views 2525
Originating Calendar Biochemistry Department Seminars

ABSTRACT:  Fidelity of mRNA translation is regulated by the accuracy of aminoacyl-tRNA synthetases, the enzymes that couple each proteinogenic amino acid with the cognate tRNA. Typically, the selectivity of the aminoacyl-tRNA synthetases towards the tRNA substrates is quite stringent and depends on the recognition of the anticodon loop and sequence among other recognition elements. Here, I will describe how two distinct tRNA-dependent enzymes, a yeast mitochondrial ThrRS (MST1) and human selenocysteine synthase (SepSecS), employ different strategies for tRNA recognition, which are in turn essential for  gene translation. In the case MST1, the enzyme binds and acts on two isoacceptor tRNAs that have completely different anticodon sequences, whereas SepSecS evolved to bind specifically an unusual selenocysteine tRNA

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University of Illinois at Urbana-Champaign
School of Chemical Sciences
106 Noyes Lab
505 S. Mathews
Urbana, IL  61801
Professor Jonathan Sweedler
Director

(217) 333-5070
(217) 333-3120 fax
jsweedle [at] illinois [dot] edu
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scs_web [at] scs [dot] illinois [dot] edu