Indonesian Students Club

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TCB Group "Clamps and clamp loaders in the archaeal/eukaryotic lineage"

SpeakerProf. Isaac K.O. Cann, UIUC - Microbiology and Animal Sciences
Date Nov 11, 2013
Time 3:00 pm - 4:00 pm  
Location BI - 3269
Sponsor Klaus Schulten - TCB Group
Contact Donna H. Fackler
Phone 300.8022
Event type Seminar/Symposium
Views 2217
Originating Calendar Beckman Main Calendar

Life on our planet can be divided into three domains: the Archaea, Eukarya and Bacteria. In all three domains of life, the speed required for DNA synthesis is only possible because of the evolution of a donut shaped protein that interacts with a replicative DNA polymerase to duplicate the genome in a processive manner. The donut-shaped proteins are loaded by a heteropentameric protein complex that harnesses energy through hydrolysis of ATP bound at its interfaces. In this presentation, I will discuss the evolution of the clamp loader in the archaeal/eukaryotic sister lineages, and provide evidence for an alternative mechanism for loading the Methanosarcina acetivorans clamp loader, an intermediate between the commonest clamp loader in the archaea and the very complex forms found in eukaryotic organisms. I will further discuss our attempt to use these processive factors to test Woese’s hypothesis of the existence of a Darwinian threshold.

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