Biochemistry Department

Biochemistry Department

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Event Detail Information

SpeakerDr. Marina Ramirez-Alvarado
Date Mar 29, 2013
Time 12:00 pm - 1:00 pm  
Location B102 CLSL
Cost Free
Sponsor SACNAS - Manuel A. Ortega and partially funded by SORF
Contact Cara L. Day
Phone 217.333.2013
Event type Seminar/Symposium
Views 2067

ABSTRACT:  The Ramirez-Alvarado team is interested in understanding the molecular mechanisms that promote protein misfolding in the context of human disease. Our team has focused its studies on Light Chain Amyloidosis, a fatal protein misfolding disease associated with a malignancy.  The disease is characterized by abnormal proliferation of plasma cells that secret large amounts of free immunoglobulin light chains.  These light chains then misfold and aggregate as amyloid fibrils in vital organs, causing organ failure and death.  Our research program is interested in determining the mutations responsible for amyloid formation and the structural basis of light chain derived toxicity.

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