Biochemistry Department

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Biochemistry Seminar: Dr. A. Joshua Wand (University of Pennsylvania) "The Dark Energy of Proteins Comes to Light"

Event Type
Seminar/Symposium
Sponsor
Dr. Stephen G. Sligar
Location
Charles G. Miller Auditorium, Room B102 Chemical & Life Sciences Laboratory
Date
Nov 1, 2013   12:00 - 1:00 pm  
Speaker
Dr. Josh Wand
Cost
Free
Originating Calendar
Biochemistry Department Seminars

ABSTRACT:  The role of conformational entropy in molecular recognition by proteins has been elusive, mostly because it has been difficult to measure. We have recently developed an empirical "entropy meter" based on a dynamical proxy that is accessed by NMR relaxation methods. Kasinath, V., Sharp, K. A. and Wand, A. J. (2013) Microscopic insights into the NMR relaxation based protein conformational entropy meter. J. Am. Chem. Soc. 135, 15092-15100. Wand, A. J. (2013) The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation. Cur. Opinion Struct. Biol. 23, 75 – 81. Marlow, M. S., Dogan, J., Frederick, K. K., Valentine, K. G., and Wand, A. J. (2010) The role of conformational entropy in molecular recognition by calmodulin.  Nature Chem. Biol. 6, 353 – 358. Frederick, K. K., Marlow, M. S., Valentine, K. G. and Wand, A. J. (2007) Conformational entropy in molecular recognition by proteins. Nature 448, 325 – 329

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