Biochemistry Department Seminars

Biochemistry Department Seminars

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Event Detail Information

Event Detail Information


Dr. Brian Kuhlman

Date Oct 4, 2013
Time 12:00 pm - 1:00 pm  

Charles G. Miller Auditorium (B102 CLSL)




Cara L. Day

Phone 217.333.2013
Event type Seminar
Views 3543

The molecular modeling program Rosetta has been used to design novel protein-protein interactions and protein switches that respond to light.  The designed interactions make use of stabilizing anchor points such as metal binding and Beta-strand interactions.  The designed photoactivable proteins incorporate the naturally occurring LOV domain from plants, and show increased binding affinity for specified binding partners in the light.  These binding events have been used to control gene transcription and protein localization with blue light.

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