Biochemistry Department Seminars

Biochemistry Department Seminars

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Event Detail Information

SpeakerDr. Eric Schmidt
Date Mar 8, 2013
Time 12:00 pm - 1:00 pm  
Location B102 CLSL
Cost Free
Sponsor Dr. Satish Nair
Contact Cara L. Day
Phone 217.333.2013
Event type Seminar/Symposium
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ABSTRACT:  Cyanobactins are ribosomally derived peptide natural products that are extensively posttranslationally modified. In exploring the biosynthesis of diverse cyanobactins in nature, we found that the enzyme sequences are highly similar (often, identical) despite producing diverse substrates. We have been working to understand these multistep pathways, where the enzymes are relatively fixed while the substrates undergo substantial modification. In so doing, we have also examined the chemical mechanisms underlying some of the posttranslational tailoring steps and synthesized diverse derivatives in vivo and in vitro for drug discovery.

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