Biochemistry Department Seminars

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Biochemistry Seminar: Dr. Eric Schmidt, University of Utah Health Sciences Center, "Substrate Evolution in Cyanobactin Biosynthesis"

Event Type
Seminar/Symposium
Sponsor
Dr. Satish Nair
Location
B102 CLSL
Date
Mar 8, 2013   12:00 - 1:00 pm  
Speaker
Dr. Eric Schmidt
Cost
Free
Contact
Cara L. Day
E-Mail
caraday@illinois.edu
Phone
217.333.2013
Views
2153

ABSTRACT:  Cyanobactins are ribosomally derived peptide natural products that are extensively posttranslationally modified. In exploring the biosynthesis of diverse cyanobactins in nature, we found that the enzyme sequences are highly similar (often, identical) despite producing diverse substrates. We have been working to understand these multistep pathways, where the enzymes are relatively fixed while the substrates undergo substantial modification. In so doing, we have also examined the chemical mechanisms underlying some of the posttranslational tailoring steps and synthesized diverse derivatives in vivo and in vitro for drug discovery.

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