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PRODID:-//University of Illinois//Web Services Calendar//EN
VERSION:2.0
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BEGIN:VEVENT
DTSTAMP:20120214T143550Z
DTSTART;TZID=America/Chicago:20091012T120000
DTEND;TZID=America/Chicago:20091012T120000
SUMMARY:Dr. William Helferich presents "Phytoestrogens and Breast Cancer:
  A Complex Story."
CREATED:20090810T130000Z
DESCRIPTION:Genistein\, found in soy products\, is a phytochemical with e
 strogenic activity.  Our research has focused on the effects dietary gen
 istein on growth of estrogen (E)-dependent mammary tumors both in vitro 
 and in vivo. Genistein enhances the proliferation of E-dependent human b
 reast cancer tumor growth. Genistin\, the glycoside form of genistein si
 mulates growth similar to that of genistein and withdrawal of either gen
 istin results in tumor regression.  We have also demonstrated that soy p
 rotein isolates processed to contain low\, medium and high amounts of is
 oflavones simulate tumor growth in a dose dependent manner.  Expression 
 of the estrogen-responsive gene\, pS2 was also induced in response to tr
 eatment with dietary genistein. Genistein can act as an estrogen agonist
  resulting in proliferation of E-dependent human breast cancer cells in 
 vivo and can negate the inhibitory effects of TAM and AIs on E-stimulate
 d growth of MCF-7 cell tumors (in vivo) implanted into ovariectomized at
 hymic mice.  These results warrant caution for women with estrogen-depen
 dent BC regarding consumption of isoflavone-containing dietary supplemen
 ts and soy ingredients high in isoflavones.
LAST-MODIFIED:20090928T130000Z
LOCATION:Room 1000 Micro and Nano Laboratory\, 208 N. Wright St.\, Urbana
 \, IL
CATEGORIES:Seminar
CONTACT:Nikki Hausmann (217) 333-4291
ORGANIZER:nhausman@illinois.edu
URL:http://illinois.edu/calendar/detail/1539?key=2000010120000101126041
UID:126041@illinois.edu
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