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PRODID:-//University of Illinois//Web Services Calendar//EN
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BEGIN:VEVENT
DTSTAMP:20120214T150121Z
DTSTART;TZID=America/Chicago:20091106T140000
DTEND;TZID=America/Chicago:20091106T140000
SUMMARY:"Gene regulatory networks:  a crossroads of physics and cell biol
 ogy"
CREATED:20090821T140000Z
DESCRIPTION:In the first part of this talk\, I will focus on a gene regul
 atory network in B lymphocytes that processes antigen receptor signal st
 rength\; quantitative modeling reveals how this network leads to an unus
 ual developmental trajectory that transiently promotes receptor affinity
  maturation and immunoglobulin class switching before leading to termina
 lly differentiated antibody secreting plasma cells.  Beyond enabling com
 peting demands of humoral immune responses to be balanced\, the network 
 architecture studied here provides a general mechanism for quantitative 
 variations in a signal to be translated to a binary choice involving tra
 nsient expression of one of the two developmental states.In the second p
 art\,  I will describe an analysis method that exploits natural cell-to-
 cell variations to substitute for artificial manipulations for inference
  of regulatory synergies.  These studies have further motivated the deve
 lopment of novel algorithms for treating systems far from equilibrium\, 
 which we are now applying to a wide range of systems.
LAST-MODIFIED:20091008T140000Z
LOCATION:144 Loomis
CATEGORIES:CPLC Seminar
CONTACT:Shawn McCormick
ORGANIZER:smmccorm@illinois.edu
URL:http://illinois.edu/calendar/detail/1968?key=2000010120000101132023
UID:132023@illinois.edu
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