In this presentation, I will outline our recent computational efforts toward developing state-of-the-art MR imaging and image analysis approaches to describe tongue anatomy and motion patterns during speech. Specifically, I will present methods to build a 3D vocal tract atlas and statistical models from structural MRI and a 4D atlas from cine-MRI to understand the standard anatomy and motion of the vocal tract during speech. When complete, this will be a comprehensive and systematic framework to characterize the relationship between tongue muscle structure and function during speech. Also, I will present a method to reveal functional organization of the tongue by determining functional units of the tongue motion. Taken together, the motion analysis framework has already been applied successfully to normal controls and glossectomy patients during speech.
Lee Josephson, Ph.D., Associate Professor, MGH– Magnetic Nanoparticles and MR: From Imaging to Assays and Back Again
The ability of Magnetic Nanoparticles (NPs) to enhance proton relaxation rates has long been recognized as a way to determine the metastatic status of normal-sized lymph nodes by MRI. Also long recognized has been the ability of magnetic NPs and MR spectrometry to serve as an in vitro assay technology. The sometimes-tortuous journey of these research concepts to commercialization, and to adaptation by the health care system, will be discussed. Finally, I’ll discuss a recent technique for synthesizing radioactive NPs termed “taking the chemistry out of radiochemistry.” What a long strange journey the trip can be, translating nanotechnology from research to the clinic and to final societal adaptation.
Neil Vasdev, Ph.D., Director of Radiochemistry MGH, Associate Professor, Harvard Medical School – Cutting-edge radiochemical methods and technologies for human PET imaging
This presentation will focus on some non-traditional approaches to prepare PET radiopharmaceuticals for new targets, and aims to show the intricacies of developing PET radiopharmaceuticals from "bench to bedside." Specifically, cutting-edge approaches and technologies for imaging the dopaminergic pathway with PET, as well as our recent work to expand beyond the “amyloid cascade hypothesis” of Alzheimer’s disease, including tauopathies, will be presented. Several of the neuroimaging agents have also been applied as oncology probes. Translating labeled compounds to PET radiopharmaceuticals and our aspiration to work towards the ultimate, albeit impossible, goal in the field: to radiolabel virtually any compound for PET will be raised as points for discussion.
Quanzheng Li, PhD, Assistant Professor – Task Based Maximization of Information in Medical Imaging
In this talk I will briefly introduce how to use signal and image processing tools to maximize the information derived from medical imaging systems for different diagnosis and prognosis tasks, and demonstrate some applications in image reconstruction (e.g. dynamic PET, time-of-flight PET and spectrum CT) , image analysis (e.g. partialvolume effect correction and treatment response evaluation) and brain network analysis.