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Theoretical and Computational Biophysics Seminar

Event Type
Seminar/Symposium
Sponsor
Theoretical and Computational Biophysics
Location
Beckman Institute, Room 3269
Date
Apr 17, 2017   3:00 pm  
Speaker
Assistant Professor Jason Ridlon
Contact
Kelly Young
E-Mail
kjhoung@illinois.edu
Phone
217-333-9734
Views
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“A POTENTIAL ROLE OF GLUCOCORTICOID METABOLISM BY GUT MICROBES IN ESSENTIAL HYPERTENSION”

ASSISTANT PROFESSOR JASON RIDLON
UNIVERSITY OF ILLINOIS - URBANA
DEPARTMENT OF ANIMAL SCIENCES

Monday, April 17, 2017
3:00 PM
Room 3269 Beckman Institute

Abstract

The gastrointestinal microbiota is now viewed as a virtual metabolic organic. This
complex microbial organ has endocrine function, including the generation of steroid
hormones reabsorbed by the host. Many of the genes encoding enzymes involved in
steroid biotransformations are unknown or poorly characterized. We have identified a
bacterial gene cluster responsible for steroid-17,20-desmolase which converts host
glucocorticoids to androstanes and androgens. These steroid metabolites are known
inhibitors of renal 11β-HSD2, an enzyme whose function is to protect the
mineralocorticoid receptor from cortisol. Inhibition of 11β-HSD2 may lead to essential
hypertension in some individuals, as evidenced by ingestion of licorice root whose
active ingredient, glycyrrhizin, is a potent 11β-HSD2 inhibitor, causing hypertension.
Recently, we have determined the structure and made substantial progress toward the
catalytic mechanism of an enzymatic “switch” that regulates androstane formation by
gut microbes. We have identified potential probiotic gut bacteria which may be useful in
preventing formation of pro-hypertensive steroids.
Research Interests Bile Acids and Salts * Microbiota * Fibrosis * Clostridium * Bacteria * Hepatic Encephalopathy *
Genes * Inflammation

A short bio can by found at the following link: http://ansci.illinois.edu/directory/jmridlon

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